Anti-Human FSCN2 (Fascin-2) Rabbit Polyclonal Antibody for WB and ELISA - O14926

Core Product Specifications and Parameters

Biological Background: Fascin-2 Function and Localization

• Fascin-2 (FSCN2), also known as retinal fascin, is an actin-bundling protein predominantly expressed in photoreceptor cells.
• It plays a central role in organizing actin filaments and is critical for photoreceptor-specific structures, including disk morphogenesis in the outer segments.
• The FSCN2 gene encodes isoforms via alternative splicing, contributing to functional diversity in the retina.
• Subcellularly, Fascin-2 localizes to the cytoplasm and cytoskeleton, and is enriched in cell projections such as stereocilia.
• Tissue specificity is high; it is localized precisely in the outer and inner segments of retinal photoreceptor cells.
• Key post-translational and functional keywords include actin-binding, and its association with retinitis pigmentosa highlights its importance in retinal health and disease.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant fusion protein covering amino acids 1-310 of human FSCN2, corresponding to the N-terminal region. This region may detect both full-length and potential N-terminal isoforms.
• For Western blot (WB), consider using whole retina lysates or photoreceptor-enriched fractions from human, mouse, or rat samples, as cross-reactivity is confirmed for mouse and rat.
• Validate the antibody in your specific experimental system, and optimize dilution factors for WB and ELISA to achieve the desired signal-to-noise ratio.
• Since Fascin-2 is a cytoskeletal protein, ensure proper sample preparation for cytoskeleton-associated proteins (e.g., inclusion of appropriate detergents).

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a leading one-stop sourcing partner for IVD raw materials, offering validated antibodies, recombinant proteins, and bulk ancillary reagents for retinal biology and actin cytoskeleton research. Whether you need optimized rabbit polyclonal antibodies like this anti-FSCN2 product or tailored technical support from concept to clinic, CamelBio accelerates your diagnostic and research workflows.