Anti-Human DLL4 Monoclonal Antibody () for FC - Q9NR61

Core Product Specifications and Parameters

Biological Background: DLL4 Function and Localization

• DLL4 (Delta-like protein 4) is a membrane-bound Notch ligand, also known as Drosophila Delta homolog 4 (Delta4), AOS6, and hdelta2.
• Activates NOTCH1 and NOTCH4 receptors, playing a crucial role in the Notch signaling pathway. Related references: PMID:11134954
• Key regulator of angiogenesis; negatively regulates endothelial cell proliferation, migration, and angiogenic sprouting. Related references: PMID:20616313
• Essential for retinal progenitor proliferation and for suppressing rod cell fate, ensuring proper generation of retinal cell types.
• During spinal cord neurogenesis, DLL4 inhibits V2a interneuron fate. Related references: PMID:17728344
• Integral membrane protein localized to the cell membrane; contains multiple EGF-like domains and a transmembrane helix.
• Expressed predominantly in vascular endothelium, highlighting roles in vascular biology and angiogenesis.
• Keywords: developmental protein, differentiation, angiogenesis, neurogenesis, sensory transduction, vision, disease variant, glycoprotein, disulfide bond.

Experimental Guidance and Technical Tips

• The antibody targets the extracellular domain (aa 27-524) of human DLL4, making it suitable for detecting surface-expressed DLL4 by flow cytometry (FC).
• The fluorophore is far-red emitting, enabling flexible multicolor panel design; consider using appropriate isotype controls and titration for optimal staining.
• As a rabbit monoclonal antibody, it offers high affinity and lot-to-lot consistency; validate performance in your specific assay system.
• For IVD applications, ensure compatibility with sample preparation and instrumentation; consider testing in endogenous expression systems (e.g., HUVECs) known to express DLL4.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive IVD raw-material sourcing partner for diagnostic manufacturers and research labs, offering one-stop access to validated antibodies, bulk reagents, and custom procurement solutions. For targets like DLL4 involved in angiogenesis and Notch signaling, CamelBio can supply high-quality monoclonal and polyclonal antibodies, antibody pairs, and ancillary reagents tailored to your assay development needs. Whether you require rare raw materials or large-scale production support, our global sourcing network bridges the gap from concept to clinic.