Anti-Human CLEC12A/CD371 Monoclonal Antibody for Flow Cytometry - Q5QGZ9-2

Core Product Specifications and Parameters

Biological Background: CLEC12A Function and Localization

• Isoform 2 of C-type lectin domain family 12 member A (CLEC12A), a single-pass type II membrane protein.
• Also known as C-type lectin-like molecule 1 (CLL-1), Dendritic cell-associated lectin 2 (DCAL-2), Killer cell C-type lectin-like receptor L1 (hKLRL1), and Myeloid inhibitory C-type lectin-like receptor (MICL).
• Encoded by the CLEC12A gene on chromosome 12 in humans.
• Predicted molecular weight of approximately 31 kDa (30762 Da as per UniProt).
• Contains a C-type lectin domain, typical of glycan-binding receptors.

Experimental Guidance and Technical Tips

• For flow cytometry, titrate the antibody to determine the optimal staining concentration for your cell type.
• Since the immunogen includes the extracellular region (aa 65-265), this antibody may be suitable for live cell staining under non-permeabilizing conditions.
• Consider using Fc receptor blocking reagents to reduce non-specific binding, especially with myeloid cell samples.
• Validate performance in your specific sample system, as antigen expression levels can vary between cell lines and primary cells.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides streamlined access to a wide range of IVD raw materials, from validated antibodies to bulk ancillary reagents. This anti-CLEC12A antibody supports myeloid cell immunophenotyping research and diagnostic assay development. Leverage our global sourcing network to secure rare-target reagents and technical support for your next project.