Anti-Human CD138 PE Monoclonal Antibody for Flow Cytometry - P18827

Core Product Specifications and Parameters

Biological Background: Syndecan-1 Function and Localization

• Syndecan-1 is a cell surface proteoglycan that carries both heparan sulfate and chondroitin sulfate chains, serving as a critical link between the cytoskeleton and the interstitial matrix.
• In collaboration with SDCBP and PDCD6IP, syndecan-1 plays a key role in the regulation of exosome biogenesis. Related references: PMID:22660413
• Syndecan-1 can induce its own expression in dental mesenchymal cells and neighboring dental epithelial cells through an MSX1-mediated pathway.
• The protein is localized to the membrane and is also secreted, notably into extracellular exosomes.
• Protein-level expression of syndecan-1 has been detected in placenta and fibroblasts.
• Syndecan-1 undergoes post-translational modifications including phosphorylation and glycosylation, and is classified as a glycoprotein, proteoglycan, and phosphoprotein.

Experimental Guidance and Technical Tips

• This antibody is generated against a recombinant fusion protein encompassing the extracellular domain of human CD138 (amino acids 23-251), ensuring specificity for the native protein.
• The PE conjugation allows direct detection in flow cytometry without the need for a secondary antibody; consider titrating the antibody to optimize signal-to-noise ratio.
• Validate the antibody in the relevant human sample system, as cross-reactivity with other species has not been reported.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research institutions with a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal antibodies, and ancillary reagents. For studies targeting CD138/Syndecan-1 in cancer, immunology, or exosome research, we offer reliable sourcing of rare-target materials and bulk supply options to streamline your development pipeline.