Anti-Human CD134/OX40 Monoclonal Antibody (PE) for Flow Cytometry - P43489

Core Product Specifications and Parameters

Biological Background: Tumor necrosis factor receptor superfamily member 4 (CD134/OX40) Function and Localization

• Encoded by the TNFRSF4 gene, also known as ACT35, OX40L receptor, and TAX transcriptionally-activated glycoprotein 1 receptor (CD134).
• Functions as the receptor for TNFSF4/OX40L/GP34, acting as a costimulatory molecule implicated in long-term T-cell immunity.
• Serves as an entry receptor for human herpesvirus 6B (HHV-6B) during microbial infection.
• Localizes to the cell membrane as a single-pass transmembrane protein with a signal peptide and an extracellular region containing repeat domains.
• Classified as a glycoprotein with disulfide bonds, contributing to its structural stability and ligand interaction.
• Keywords highlight its role in host-virus interaction, disease variants, and its characterization through 3D structure and proteomics.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the extracellular domain (amino acids 29-216) of human CD134/OX40; the antibody is expected to recognize the native cell surface receptor.
• For flow cytometry, titrate the antibody to determine optimal concentration for your specific cell type and experimental conditions.
• Ensure appropriate isotype controls are used for accurate gating and analysis.
• Verify specificity using CD134/OX40-expressing and non-expressing cell lines.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. For immunological targets like CD134/OX40, we offer PE-conjugated monoclonal antibodies and can source rare target raw materials to support your assay development from concept to clinic.