Anti-Human CD11b Monoclonal Antibody for FC - P11215

Core Product Specifications and Parameters

Biological Background: CD11b (Integrin alpha-M) Function and Localization

• Integrin ITGAM/ITGB2 (CD11b/CD18) mediates adhesive interactions in myeloid cells and serves as the CR3 receptor for iC3b fragment, enabling uptake of complement-coated pathogens. Related references: PMID:20008295 PMID:9558116
• It functions as a receptor for fibrinogen and factor X, likely through recognition of R-G-D peptides, and interacts with fibrinogen gamma chain P1/P2 peptides.
• Regulates neutrophil migration, contributing to innate immune responses. Related references: PMID:28807980
• In complex with ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF-primed neutrophils. Related references: PMID:21193407
• Acts as a receptor for ICAM1 on endothelial cells, facilitating neutrophil-endothelial adhesion. Related references: PMID:1980124
• May regulate phagocytosis-induced apoptosis in extravasated neutrophils and play roles in mast cell development and microglia-mediated neuronal apoptosis during brain development (by similarity).
• Localized to the cell membrane and membrane rafts, with predominant expression in monocytes and granulocytes.
• Key structural and functional features: calcium-binding, cell adhesion, disulfide bonds, glycoprotein, innate immunity, integrin, magnesium-binding, metal-binding, and transmembrane domains.

Experimental Guidance and Technical Tips

• This monoclonal antibody was generated using a synthetic peptide immunogen; consider peptide blocking experiments to confirm specificity in your assay.
• For flow cytometry, titrate the antibody to determine optimal staining concentration for your cell type of interest; always include appropriate isotype controls.
• CD11b is highly expressed on monocytes and granulocytes—validate performance in human PBMCs or isolated leukocyte populations under relevant activation conditions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated IVD raw material partner for diagnostic manufacturers, labs, and research institutes, offering end‑to‑end support from concept to clinic. This anti-CD11b antibody addresses critical immunology and inflammation research needs, and we can supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents to accelerate your assay development. For rare-target raw-material sourcing, contact our team to streamline your procurement process.