Anti-HSPB8/HSP22 Rabbit Monoclonal Antibody for WB, IF/ICC, ELISA - Q9UJY1

Core Product Specifications and Parameters

Biological Background: HSPB8/HSP22 Function and Localization

• Also known as HSP22, alpha-crystallin C chain, E2IG1, and protein kinase H11; belongs to the small heat shock protein (sHSP) family.
• Functions as a key component of chaperone-assisted selective autophagy (CASA), particularly critical for protein quality control in mechanically strained tissues like muscle.
• Facilitates the clearance of misfolded proteins and aggregates, displaying temperature-dependent chaperone activity.
• Localizes to both the cytoplasm and the nucleus.
• Predominantly expressed in skeletal muscle and heart.
• Linked to neurodegenerative diseases: mutations are associated with Charcot-Marie-Tooth disease type 2L (CMT2L) and distal hereditary motor neuropathy type IIA (dHMN2A), as well as myofibrillar myopathy.
• Subject to post-translational modifications including phosphorylation and methylation.

Experimental Guidance and Technical Tips

• The immunogen is an N-terminal peptide (aa 1-100); confirm epitope accessibility in your experimental conditions.
• For WB, expect a band at ~22 kDa; use appropriate molecular weight markers for verification.
• For IF/ICC, optimize permeabilization to access nuclear and cytoplasmic pools.
• Validate antibody performance in relevant sample matrices (e.g., human muscle lysates) before large-scale experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This anti-HSPB8/HSP22 monoclonal antibody facilitates research into autophagy, muscle biology, and neuropathies. Beyond antibodies, CamelBio offers validated antibody pairs, bulk ancillary reagents, and rare target raw-material sourcing to support your IVD development needs.