Anti-Hsc70-interacting protein (HIP) Rabbit pAb - P50502

Core Product Specifications and Parameters

Biological Background: Hsc70-interacting protein Function and Localization

• Hsc70-interacting protein (HIP), also designated ST13, is a cytoplasmic co-chaperone that directly interacts with the molecular chaperone HSC70.
• One HIP oligomer binds the ATPase domains of at least two HSC70 molecules, stabilizing the ADP-bound state with high substrate affinity (By similarity).
• The protein is subject to post-translational modifications including acetylation and phosphorylation, which may regulate its chaperone activity.
• HIP is also known as progesterone receptor-associated p48, aging-associated protein 2, and renal carcinoma antigen NY-REN-33, suggesting roles in diverse cellular pathways.
• According to UniProt, HIP contains TPR repeat domains and has been identified by direct protein sequencing.
• Subcellular localization is predominantly cytoplasmic.

Experimental Guidance and Technical Tips

• Since the immunogen spans the full-length human HIP protein (aa 1-369), the antibody may recognize native and denatured forms; however, for Western blot, we recommend denaturing and reducing conditions with appropriate blocking.
• The reported cross-reactivity with mouse and rat allows use in common model organisms; nonetheless, researchers should validate performance in their specific samples.
• For ELISA, consider using recombinantly expressed HIP as a coating antigen and optimizing antibody concentration to achieve desired sensitivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop sourcing partner for IVD raw materials, supporting diagnostic manufacturers and laboratories from early research to clinical applications. This anti-HIP antibody is part of our validated catalog of chaperone pathway reagents, ideal for protein folding and stress response studies. Beyond standard offerings, we provide custom antibody screening, bulk reagent supply, and rare-target sourcing to streamline your assay development.