Anti-HNRNPR Polyclonal Antibody for WB, IHC-P, ELISA - O43390

Core Product Specifications and Parameters

Biological Background: HNRNPR Function and Localization

• HNRNPR (Heterogeneous nuclear ribonucleoprotein R) is a member of the hnRNP family of RNA-binding proteins, encoded by the HNRNPR gene (GeneID: 10236).
• As a component of ribonucleosomes, HNRNPR participates in the processing of precursor mRNA (pre-mRNA) in the nucleus, including splicing and transport.
• The protein localizes predominantly to the nucleus, specifically the nucleoplasm, but has also been detected in the cytoplasm and microsomal fraction.
• HNRNPR undergoes various post-translational modifications such as acetylation and ubiquitination (Ubl conjugation), which may regulate its function and stability.
• Alternative splicing of HNRNPR generates multiple isoforms, contributing to functional diversity.
• Mutations in HNRNPR have been associated with intellectual disability, highlighting its importance in neurological development.
• The protein contains RNA-binding motifs and repetitive elements, facilitating its interaction with RNA and other spliceosome components.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (aa 500–end) of human HNRNPR; thus, the antibody is expected to recognize full-length and C-terminal isoforms.
• For Western blot, consider using a positive control lysate from human, mouse, or rat cells to verify the expected band at ~71 kDa.
• In immunohistochemistry (IHC-P), nuclear staining is anticipated; validate the staining pattern using appropriate tissue sections.
• For ELISA, the peptide immunogen may be used as a positive control to assess antibody binding specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and researchers with one-stop access to IVD raw materials for mRNA processing and spliceosome studies. Our portfolio includes validated antibody pairs, optimized polyclonal antibodies like anti-HNRNPR, and ancillary reagents for assay development. We also source rare-target raw materials, streamlining your journey from concept to clinic.