Anti-HNRNPCL1 Rabbit Polyclonal Antibody for WB and ELISA - O60812

Core Product Specifications and Parameters

Biological Background: HNRNPCL1 Function and Localization

• HNRNPCL1 (Heterogeneous nuclear ribonucleoprotein C-like 1) is a member of the hnRNP family, sharing similarity with core hnRNP proteins C1 and C2.
• It is thought to contribute to nucleosome assembly by neutralizing basic core hnRNP proteins, facilitating chromatin organization.
• The protein localizes to the nucleus, consistent with its role in nuclear RNA processing and ribonucleoprotein complex formation.
• Containing a coiled-coil domain, HNRNPCL1 likely participates in protein-protein interactions within ribonucleoprotein complexes.
• HNRNPCL1 is classified as a reference proteome component, underscoring its potential functional relevance in human biology.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (amino acids 200 to C-terminus) of human HNRNPCL1; antibody reactivity may be influenced by post-translational modifications in this region.
• For Western blot, a band near 32 kDa is anticipated in human cell lysates; consider using nuclear extracts to enrich target detection.
• As a polyclonal antibody, it may exhibit slight batch-to-batch variability; include positive and negative controls to ensure consistent performance.
• For ELISA, optimize coating antigen and detection antibody concentrations using a checkerboard titration to achieve optimal signal-to-noise ratios.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with seamless access to high-quality IVD raw materials. This anti-HNRNPCL1 polyclonal antibody supports studies in chromatin biology and nucleosome assembly. Beyond antibodies, we offer validated antibody pairs, optimized monoclonal/polyclonal preparations, bulk ancillary reagents, and rare target raw-material sourcing to accelerate your assay development and scale-up.