Anti-HKDC1 Rabbit Polyclonal Antibody for WB and ELISA - Q2TB90

Core Product Specifications and Parameters

Biological Background: HKDC1 Function and Localization

• HKDC1 (hexokinase domain-containing protein 1) is a hexokinase that catalyzes the phosphorylation of hexose to hexose 6-phosphate, although with very low activity compared to other hexokinases. Related references: PMID:30517626
• Plays a role in glucose homeostasis and hepatic lipid accumulation.
• Required to maintain whole-body glucose homeostasis during pregnancy, though additional evidence is needed to confirm this role.
• Belongs to the hexokinase family and features ATP-binding and nucleotide-binding domains.
• Localizes to the cytoplasm, mitochondrial membrane, and photoreceptor inner segment.
• Widely expressed, with high protein levels in the brush border of the small and large intestines, pancreatic acinar centrocytes, lung alveolar macrophages, and thyroid follicular epithelium.
• Associated with keywords: Alternative splicing, Glycolysis, Kinase, Transferase, and Retinitis pigmentosa.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide within the amino acid 150–250 region of human HKDC1. This suggests the antibody likely recognizes linear epitopes, making it suitable for denaturing techniques such as Western blotting.
• For ELISA applications, consider using the immunizing peptide or recombinant HKDC1 protein as a coating antigen to optimize assay conditions.
• Since cross-reactivity is listed only for human, validate reactivity in other species if required for your experimental setup.
• As a polyclonal antibody, it may exhibit lot-to-lot variability; include appropriate controls and validate each new lot.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio empowers diagnostic manufacturers and research teams with efficient access to high-quality IVD raw materials. This anti-HKDC1 antibody supports investigations into glucose metabolism and hexokinase biology. Beyond this product, we offer one-stop sourcing for validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare-target raw materials to accelerate your diagnostic development.