Anti-GTPBP6 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - O43824

Core Product Specifications and Parameters

Biological Background: GTPBP6 Function and Localization

• GTPBP6, also known as pseudoautosomal GTP-binding protein-like (PGPL), is a putative GTP-binding protein encoded by the GTPBP6 gene.
• It belongs to the TRAFAC class translation factor GTPase superfamily and features a GTP-binding domain, essential for nucleotide binding and hydrolysis.
• The protein contains conserved motifs for magnesium and metal ion binding, which are critical for its GTPase activity.
• Ubiquitously expressed across human tissues, suggesting a fundamental cellular role.
• The three-dimensional structure of GTPBP6 has been resolved, contributing to understanding its molecular function.
• Identified through proteomics approaches as part of the reference proteome.
• As a reference proteome protein, it is a key member of the human proteome.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 140-350 of human GTPBP6, covering the core GTP-binding domain, which may enhance detection specificity.
• Recommended applications include WB (expected band size ~57 kDa), IF/ICC, and ELISA. Validate with appropriate positive and negative controls.
• Due to cross-reactivity with mouse and rat, this antibody is suitable for comparative species studies. Optimize assay conditions for each species.
• For WB, consider using whole-cell lysates from human, mouse, or rat tissues, as GTPBP6 is ubiquitously expressed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting. This anti-GTPBP6 polyclonal antibody is part of our extensive catalogue of validated antibodies for GTPase research. From bulk ancillary reagents to custom rare-target sourcing, we bridge the gap from concept to clinic, supporting your entire development pipeline.