Anti-GSTO2 Rabbit Polyclonal Antibody for WB, IHC-P, IF/ICC, ELISA - Q9H4Y5

Core Product Specifications and Parameters

Biological Background: Glutathione S-transferase omega-2 Function and Localization

• GSTO2, also known as glutathione S-transferase omega 2-2 (GSTO 2-2), belongs to the omega class of glutathione S-transferases and shares structural similarity with GSTO1.
• It exhibits glutathione-dependent thiol transferase activity and functions as a dehydroascorbate reductase, contributing to the recycling of ascorbic acid (vitamin C).
• GSTO2 plays a role in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA(V)).
• The protein is encoded by the GSTO2 gene (GeneID: 119391) and undergoes alternative splicing, yielding different isoforms.
• Tissue expression analysis reveals widespread distribution with strongest expression in the testis, and detectable levels in liver, kidney, skeletal muscle, and prostate.
• GSTO2 is classified as an oxidoreductase and transferase, highlighting its dual enzymatic functions.
• The native molecular weight is approximately 28 kDa, consistent with the 28254 Da predicted by UniProt.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 124-243 of human GSTO2, which may facilitate recognition of both native and denatured forms in various assays.
• For Western blot (WB), a band around 28 kDa is expected; consider using appropriate loading controls to confirm specificity.
• In immunohistochemistry (IHC-P), positive staining may be observed in tissues with high expression (e.g., testis, liver); optimize antigen retrieval and antibody dilution.
• Cross-reactivity with mouse and rat is reported, enabling multi-species studies; validate in the relevant sample system to ensure consistent performance.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories a comprehensive one-stop sourcing platform for IVD raw materials. This anti-GSTO2 antibody supports investigations into glutathione metabolism, oxidative stress, and arsenic toxicity pathways. Beyond this product, we provide validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare-target raw-material sourcing to streamline your development from concept to clinic.