Anti-GSTM2 Rabbit Polyclonal Antibody for WB, ELISA - P28161

Core Product Specifications and Parameters

Biological Background: GSTM2 Function and Localization

• GSTM2 encodes a glutathione S-transferase belonging to the Mu class, with an alternative splicing variant detected.
• Catalyzes the conjugation of reduced glutathione to exogenous and endogenous hydrophobic electrophiles, facilitating detoxification.
• Involved in the formation of novel hepoxilin regioisomers, a process critical in lipid mediator biosynthesis. Related references: PMID:21046276
• Localizes to the cytoplasm, consistent with its role in intracellular glutathione-dependent reactions.
• Expressed at high levels in muscle tissue, suggesting a specialized function in that organ.
• Annotated as a phosphoprotein, indicating potential regulation by post-translational modification.

Experimental Guidance and Technical Tips

• The immunogen spans nearly the full-length protein; it may detect both full-length and potential splice variants in Western blot.
• For Western blot, a band around 26 kDa is expected; validate with appropriate positive controls (e.g., human muscle lysate).
• Cross-reactivity with mouse is reported; consider sequence homology when planning cross-species experiments.
• As a polyclonal antibody, lot-to-lot consistency can vary; consider testing new lots with reference samples.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a reliable supply chain for GSTM2-targeted research reagents, supporting studies in glutathione metabolism, detoxification pathways, and lipid biochemistry. We offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and can source rare targets to streamline your IVD and research applications. Partner with us for efficient, end-to-end raw material procurement.