Anti-GRINA Polyclonal Antibody for WB, ELISA - Q7Z429

Core Product Specifications and Parameters

Biological Background: GRINA Function and Localization

• GRINA (Glutamate [NMDA] receptor-associated protein 1), also known as Protein lifeguard 1, NMDARA1, LFG1, TMBIM3, and HNRGW, is encoded by the GRINA gene.
• It functions as a potential apoptotic regulator, suggesting a role in cell death and survival pathways.
• GRINA localizes to cellular membranes and is a multi-pass transmembrane protein.
• The protein contains transmembrane BAX inhibitor motifs, characteristic of the TMBIM family, which are involved in apoptosis modulation.
• It is identified as a reference proteome component and has been detected in proteomics studies.
• Structural predictions indicate multiple transmembrane helices, consistent with its membrane-bound nature.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-100) of human GRINA; consider this epitope location when interpreting detection results.
• For Western blot, the predicted molecular weight is 41 kDa; validate in the relevant sample system.
• This antibody has been tested in ELISA; for quantitative analysis, consider performing a standard curve with known antigen concentrations.
• Since cross-reactivity is reported for mouse and rat, users may validate the antibody in these species, but homology of the epitope region should be assessed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to IVD raw materials, including validated antibodies like this GRINA polyclonal antibody for apoptosis research. Beyond antibodies, our portfolio includes optimized antibody pairs, bulk ancillary reagents, and sourcing support for rare targets to accelerate your assay development from concept to clinic.