Anti-GPX1 Monoclonal Antibody for WB, IHC-P, ELISA - P07203

Core Product Specifications and Parameters

Biological Background: GPX1 Function and Localization

• GPX1 encodes glutathione peroxidase 1, also known as cellular glutathione peroxidase, a selenoprotein antioxidant enzyme.
• It catalyzes the glutathione-dependent reduction of hydroperoxides, including hydrogen peroxide, organic hydroperoxides, and fatty acid-derived hydroperoxides, thereby regulating cellular redox homeostasis. Related references: PMID:11115402, PMID:36608588
• In platelets, GPX1 specifically reduces 12-hydroperoxyeicosatetraenoic acid, a metabolite of the arachidonate 12-lipoxygenase pathway.
• Subcellular localization includes both cytoplasm and mitochondrion.
• Post-translational modifications include acetylation and phosphorylation; it contains selenocysteine, classifying it as a selenoprotein.
• The protein has a molecular mass of approximately 22 kDa and is subject to alternative splicing.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide within amino acids 100-200; this antibody may recognize linear epitopes, making it suitable for applications involving denatured proteins such as Western blotting.
• For WB, expect a band around 22 kDa; validate in the relevant sample system with appropriate positive and negative controls.
• For IHC-P, consider using platelet-rich tissues as positive control; perform antigen retrieval if necessary.
• Cross-reactivity predicted with mouse and rat based on sequence homology; validate performance in these species.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—supporting projects from concept to clinic. This anti-GPX1 monoclonal antibody targets a key antioxidant enzyme, making it valuable for oxidative stress-related research and assay development. Through our integrated supply network, we offer validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to meet your diagnostic development needs.