Anti-GPR108 Rabbit Polyclonal Antibody for WB, ELISA - Q9NPR9

Core Product Specifications and Parameters

Biological Background: GPR108 Function and Localization

• GPR108, also known as Lung seven transmembrane receptor 2 (LUSTR2), is a membrane protein encoded by the GPR108 gene.
• It may play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response.
• GPR108 plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5, possibly mediating endosomal escape or trafficking to the nucleus.
• It localizes to the Golgi apparatus, including the cis-Golgi network membrane and trans-Golgi network membrane.
• The protein is a glycoprotein with transmembrane helices and a signal peptide.
• Keywords include Host-virus interaction, indicating its role in viral entry mechanisms.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 33-260 of human GPR108; this antibody may recognize conformational epitopes, so consider testing in native versus denaturing conditions for WB.
• For Western blot, the predicted molecular weight is 61 kDa (protein weight) or 60.6 kDa (UniProt). Due to glycosylation, the observed band may shift; validate in the relevant sample system.
• Reported cross-reactivity with mouse and rat suggests sequence homology in the immunogen region; verify specificity for these species in your assays.
• For ELISA applications, consider using the recombinant protein immunogen as a positive control.
• Given the Golgi localization, cell fractionation or enrichment may improve detection sensitivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop sourcing bridge for IVD raw materials, providing access to validated antibodies like this anti-GPR108 polyclonal for studying Golgi function and AAV transduction. Beyond single antibodies, we offer optimized monoclonal/polyclonal antibodies, validated antibody pairs, and bulk ancillary reagents. Our network enables rare target raw-material sourcing to support your diagnostic development from concept to clinic.