Anti-GP6/GPVI Monoclonal Antibody for FC, ELISA - Q9HCN6

Core Product Specifications and Parameters

Biological Background: GP6 Function and Localization

• Platelet glycoprotein VI (GPVI) is a major collagen receptor mediating platelet adhesion and activation upon vascular injury.
• GPVI signaling involves the FcR gamma-chain and Src-family kinases (likely FYN or LYN), leading to SYK activation, LAT phosphorylation, and PLCG2-mediated calcium mobilization.
• The receptor promotes platelet procoagulant activity, contributing to thrombin generation and fibrin formation, and is implicated in both arterial and venous thrombosis.
• GPVI is a type I transmembrane glycoprotein containing immunoglobulin-like domains and is expressed primarily on megakaryocytes and platelets.
• Alternative splicing generates multiple transcript variants; disease-associated variants have been linked to platelet disorders.
• Post-translational modifications include disulfide bond formation and glycosylation, which are critical for receptor structure and function.
• As a key hemostatic receptor, GPVI serves as a therapeutic target for antithrombotic drug development.

Experimental Guidance and Technical Tips

• The immunogen spans the extracellular domain (aa 21-267), making this antibody potentially suitable for detecting surface-expressed GPVI in flow cytometry.
• For ELISA, consider using recombinant GPVI protein or platelet lysates; optimization of coating conditions and antibody dilution is recommended.
• Given the role of GPVI in thrombosis, this antibody may be useful in studying platelet function and screening antithrombotic compounds.
• Validate the antibody in your specific sample system, as expression levels can vary depending on platelet activation state.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes with a comprehensive sourcing solution for IVD raw materials. This anti-GPVI monoclonal antibody supports thrombosis and hemostasis research, and we offer validated antibody pairs, recombinant proteins, and bulk ancillary reagents to accelerate your assay development. Whether you need rare-target raw materials or optimized monoclonals, CamelBio bridges the gap from concept to clinic.