Anti-GNG3 Polyclonal Antibody for WB, ELISA - P63215

Core Product Specifications and Parameters

Biological Background: GNG3 Function and Localization

• Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 (GNG3) is a member of the gamma subunit family of heterotrimeric G proteins, which modulate various transmembrane signaling systems.
• G protein gamma subunits, along with beta subunits, are essential for GTPase activity, facilitating GDP/GTP exchange, and mediating G protein-effector interactions.
• GNG3 is localized to the cell membrane, consistent with its role as a membrane-associated signaling transducer.
• The protein undergoes post-translational modifications including prenylation and methylation, which are important for membrane targeting and protein-protein interactions.
• GNG3 is also classified as a phosphoprotein and lipoprotein, suggesting regulatory roles through phosphorylation and lipid modifications.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the full-length human GNG3 (aa 1-75), suggesting the antibody may detect native and denatured forms, but validation in the relevant sample system is recommended.
• For Western blot, consider using a low molecular weight marker range, as GNG3 has a predicted molecular weight of approximately 8 kDa.
• Cross-reactivity with mouse and rat indicates potential utility in rodent model studies; however, we recommend verifying specificity in the target species and tissue.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic and research laboratories with comprehensive access to IVD raw materials, including validated antibodies for signal transduction research. Our GNG3 rabbit polyclonal antibody supports studies in G protein-coupled receptor signaling, and we offer bulk supply and technical consultation to accelerate your assay development. Count on us for tailored monoclonal/polyclonal antibody sourcing and ancillary reagents.