Anti-GMIP Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q9P107

Core Product Specifications and Parameters

Biological Background: GMIP Function and Localization

• GMIP, also known as ARHGAP46, is a GEM-interacting protein that acts as a GTPase-activating protein (GAP) for RhoA.
• It stimulates the intrinsic GTPase activity of RhoA, promoting the hydrolysis of GTP to GDP and thereby inactivating the small GTPase.
• The protein contains a zinc-finger domain and a coiled coil region, typical of RhoGAP family members, which are essential for its catalytic activity.
• Multiple isoforms are produced by alternative splicing, which may vary in tissue distribution and regulatory functions.
• GMIP is classified as a phosphoprotein, indicating that its activity or interactions may be modulated by phosphorylation.
• The full-length protein has a predicted molecular weight of approximately 107 kDa.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-91) of human GMIP; consider this when assessing isoform specificity.
• For WB, an expected band near 107 kDa is anticipated; optimize blocking and antibody dilution for your sample type.
• IHC-P may require antigen retrieval; validate staining with appropriate positive and negative controls.
• ELISA performance should be verified using recombinant protein or lysates; include a standard curve for quantification.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with integrated access to IVD raw materials, including validated antibodies like this GMIP pAb for RhoA signaling studies. Our portfolio also covers ancillary reagents and supports rare‑target material sourcing. From concept to clinic, we offer consistent supply solutions to accelerate your assay development.