Anti-GLYR1 Polyclonal Antibody for WB, ELISA - Q49A26

Core Product Specifications and Parameters

Biological Background: GLYR1 (Cytokine-like nuclear factor N-PAC) Function and Localization

• GLYR1 (also known as N-PAC, NP60, hNDF) is a cytokine-like nuclear factor with chromatin gene reader activity, involved in chromatin modification and regulation of gene expression. Related references: PMID:23260659 PMID:30970244
• Acts as a nucleosome-destabilizing factor, recruited to genes during transcriptional activation; recognizes and binds histone H3 and DNA without preference for specific epigenetic marks. Related references: PMID:20850016 PMID:29759984 PMID:30970244
• Interacts with KDM1B, enhancing its histone demethylase activity to facilitate Pol II transcription through nucleosomes and stimulates EP300-mediated acetylation of histone H3K56. Related references: PMID:23260659 PMID:29759984 PMID:30970244
• Together with GATA4, co-regulates a set of heart development genes, playing a role in cardiomyocyte differentiation. Related references: PMID:35182466
• Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha, promoting phosphorylation of MAPK14 and ATF2. Related references: PMID:16352664
• Localizes to the nucleus and associates with chromosomes, consistent with its role in chromatin remodeling and gene expression.
• Annotated keywords include: 3D-structure, Alternative splicing, Chromosome, DNA-binding, Isopeptide bond, Nucleus, Phosphoprotein, Proteomics identification, Reference proteome, Ubl conjugation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 70–270 of human GLYR1, a region implicated in histone and DNA interactions; consider using nuclear extracts to enrich the target for Western blot detection.
• Reported cross‑reactivity with human, mouse, and rat makes this antibody suitable for cross‑species studies; always validate performance in your specific experimental system.
• For ELISA applications, ensure that the coating antigen aligns with the immunogen sequence to preserve epitope recognition and signal specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides comprehensive IVD raw‑material sourcing, from validated antibody pairs and optimized monoclonal/polyclonal antibodies to bulk ancillary reagents, supporting seamless integration into your assay development pipelines. For chromatin remodeling, transcriptional regulation, and nucleosome dynamics research, this anti-GLYR1 polyclonal antibody represents a reliable tool backed by our global supply network. Wherever your diagnostic development leads, CamelBio bridges the gap between concept and clinic with rare‑target sourcing and expert technical support.