Anti-Glycophorin C (GYPC) Polyclonal Antibody for WB, ELISA - P04921

Core Product Specifications and Parameters

Biological Background: Glycophorin-C Function and Localization

• Glycophorin-C is a minor sialoglycoprotein of the human erythrocyte membrane, characterized by abundant sialic acid modification.
• It plays a critical role in maintaining red cell stability and mechanical properties.
• The extracellular domain harbors the Gerbich blood group antigens and serves as the receptor for Plasmodium falciparum merozoites, implicating it in malaria pathogenesis.
• As a single-pass transmembrane protein, it is anchored in the cell membrane with its N-terminal domain exposed extracellularly.
• Alternative splicing generates Glycophorin-D and IsoGPC; while Glycophorin-C is erythrocyte-specific, the other isoforms are ubiquitously expressed.
• The protein undergoes phosphorylation and its structure has been solved by experimental methods.
• Direct protein sequencing has confirmed its identity, underscoring its well-characterized nature.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal extracellular region (amino acids 1-128) of human GYPC, targeting an area rich in antigenic epitopes.
• This polyclonal antibody is suitable for Western blotting (theoretical weight ~14 kDa, though glycosylation may shift migration) and ELISA.
• Cross-reactivity with mouse GYPC allows application in murine models; validate in the relevant sample system (e.g., erythrocyte lysates) to confirm performance.
• For optimal results, consider standard optimization of antibody dilution and sample preparation for each assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to high-quality IVD raw materials, including validated antibodies, antigens, and ancillary reagents. The Glycophorin C (GYPC) rabbit polyclonal antibody supports studies in erythrocyte biology and infectious disease (e.g., malaria), and our team can assist with bulk sourcing, customized antibody pairs, and technical consultation to streamline your assay development.