Anti-GLUT2/SLC2A2 Polyclonal Antibody for WB, IF-P, IHC-P, ELISA - P11168

Core Product Specifications and Parameters

Biological Background: GLUT2/SLC2A2 Function and Localization

• Solute carrier family 2, facilitated glucose transporter member 2 (GLUT2/SLC2A2) is a member of the GLUT family of facilitative sugar transporters.
• It mediates the transport of hexoses including glucose, fructose, and galactose across the cell membrane (PubMed:16186102, PubMed:23396969, PubMed:28083649). Related references: PMID:16186102 PMID:23396969 PMID:28083649
• In hepatocytes and pancreatic beta cells, GLUT2 facilitates bidirectional glucose transport, contributing to glucose sensing and homeostasis (PubMed:8027028). Related references: PMID:8027028
• It may also participate in transcellular glucose transport in the small intestine and kidney, cooperating with Na+/glucose cotransporters (PubMed:3399500). Related references: PMID:3399500
• GLUT2 has been shown to transport dehydroascorbate and urate (PubMed:23396969, PubMed:40209957). Related references: PMID:23396969 PMID:40209957
• The protein is localized to the cell membrane and is primarily expressed in liver, insulin-producing beta cells, small intestine, and kidney.
• Post-translational modifications include glycosylation and phosphorylation; the SLC2A2 gene undergoes alternative splicing.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide corresponding to the N-terminal region (amino acids 1–100) of human GLUT2/SLC2A2; consider that this may enable detection of multiple isoforms if the epitope is conserved.
• For Western blot (WB), expect a band around 57 kDa; validate expression in relevant cell lines or tissues such as liver or pancreatic beta cells.
• For immunofluorescence (IF) and immunohistochemistry (IHC-P), appropriate antigen retrieval and permeabilization methods should be optimized; consider using positive control tissues like liver or pancreas.
• For ELISA, the antibody may be used as a capture or detection reagent; titrate and validate against recombinant or endogenous targets in the relevant sample matrix.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a one-stop sourcing solution for IVD raw materials, supporting manufacturers and researchers from concept to clinic. This anti-GLUT2/SLC2A2 polyclonal antibody is ideal for glucose transport and metabolic disease research, and we can supply validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to streamline your diagnostic development.