Anti-GluR2+GluR3 Rabbit Monoclonal Antibody for WB, IP, ELISA - P42262 / P42263

Core Product Specifications and Parameters

Biological Background: Glutamate Receptor 2 (GluR2) and AMPA Receptor Function

• Acts as an ionotropic glutamate receptor and ligand-gated cation channel activated by L-glutamate, AMPA, quisqualate, and kainate. Related references: PMID:20614889, PMID:31300657, PMID:8003671
• Mediates fast excitatory synaptic transmission critical for communication between neurons in the central nervous system. Related references: PMID:14687553
• Upon agonist binding, undergoes a conformational change that opens the channel pore, allowing influx of Na⁺ and Ca²⁺ ions. Related references: PMID:20614889, PMID:8003671
• Rapidly desensitizes after activation and, in complex with auxiliary subunits (CACNG4, CACNG7, CACNG8), exhibits resensitization with sustained glutamate exposure.
• Subject to RNA editing at the Q/R site, which critically reduces calcium permeability and shapes channel properties; also undergoes alternative splicing.
• Localized to the postsynaptic membrane and postsynaptic density of excitatory synapses, ensuring precise signal reception.
• Associated with neurological and neurodevelopmental disorders, including autism spectrum disorder, epilepsy, and intellectual disability.

Experimental Guidance and Technical Tips

• The immunogen used for this antibody is a synthetic peptide spanning amino acids 784-883 of human GluR2 (P42262); this region shows high homology with GluR3, enabling dual reactivity.
• For Western blot (WB), a band at ~98 kDa is expected in brain lysates; adjust loading and antibody concentration for optimal detection.
• In immunoprecipitation (IP) and ELISA applications, validate the antibody in relevant sample systems expressing GluR2 and/or GluR3.
• Cross-reactivity with mouse and rat orthologs is supported; therefore, consider species-appropriate positive controls in comparative studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw-material procurement for diagnostic and research communities, offering validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. This anti-GluR2+GluR3 rabbit monoclonal antibody supports neuroscience and neurology research, and our one-stop service can efficiently source rare targets and custom formulations to accelerate your project from concept to clinic.