Anti-GLRA2 Rabbit Polyclonal Antibody for WB and ELISA - P23416

Core Product Specifications and Parameters

Biological Background: GLRA2 Function and Localization

• GLRA2 encodes the alpha-2 subunit of the glycine receptor, a pentameric ligand-gated ion channel that mediates fast inhibitory neurotransmission in the central nervous system.
• Forms heteromeric glycine-gated chloride channels, allowing chloride influx and hyperpolarization of the postsynaptic membrane.
  Related references: PMID:15302677, PMID:16144831, PMID:2155780
• Contributes to inhibitory postsynaptic currents and down-regulation of neuronal excitability.
  Related references: PMID:25445488
• Plays a role in synaptic plasticity and cellular responses to ethanol.
  Related references: PMID:23895467
• Localizes to the postsynaptic cell membrane, synapse, and cell projections.
• Features include disulfide bonds, glycosylation, zinc binding, and alternative splicing. Mutations are linked to non-syndromic X-linked intellectual disability (MRXSP).

Experimental Guidance and Technical Tips

• The immunogen (amino acids 350–420) corresponds to the intracellular C-terminal domain of human GLRA2, which is well‑conserved across mouse and rat, supporting cross‑reactivity.
• For Western blot, the predicted molecular weight is 52 kDa; reducing SDS‑PAGE and appropriate transfer conditions are recommended.
• In ELISA applications, consider using an indirect ELISA format with the recombinant immunogen as a positive control.
• Validate the antibody in appropriate sample systems (e.g., brain lysates) known to express GLRA2 to confirm specificity.

CamelBio: Your One-Stop Sourcing Bridge

As your one‑stop IVD raw‑material sourcing partner, CamelBio offers validated antibodies like this anti‑GLRA2 polyclonal antibody for neuroscience research and diagnostic development. We provide comprehensive supply solutions, including antibody pairs, recombinant antigens, and ancillary reagents, supporting your entire assay development workflow from concept to clinic.