Anti-GHSR Rabbit Polyclonal Antibody for WB, ELISA - Q92847

Core Product Specifications and Parameters

Biological Background: GHSR Function and Localization

• GHSR encodes a specific G protein-coupled receptor for ghrelin, an appetite-regulating peptide hormone predominantly produced in the stomach (PubMed:35027551, PubMed:39833471). Related references: PMID:35027551 PMID:39833471
• Receptor activation by ghrelin stimulates appetite and promotes growth hormone secretion from the pituitary gland (PubMed:11322507, PubMed:10604470, PubMed:35027551). Related references: PMID:11322507 PMID:10604470 PMID:35027551
• Beyond ghrelin, GHSR binds synthetic growth hormone-releasing peptides (GHRPs) and non-peptide secretagogues such as MK-0677 and adenosine (PubMed:11322507, PubMed:10604470). Related references: PMID:11322507 PMID:10604470
• The receptor is localized to the cell membrane and is primarily expressed in the pituitary and hypothalamus.
• GHSR undergoes alternative splicing and contains disulfide bonds; it is classified as a glycoprotein and a member of the GPCR family. Mutations are associated with growth disorders, including dwarfism.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide within the N‑terminal region (amino acids 1–100) of human GHSR. This region may confer target specificity; blocking peptide controls are advisable for validation.
• Western blot (WB) and ELISA are listed applications; optimal antibody concentrations and detection conditions should be determined empirically in the relevant sample system.
• Cross‑reactivity with mouse and rat is indicated, making this antibody a candidate for translational models using rodent tissues.
• The predicted protein weight is 41 kDa; however, glycosylation or other post‑translational modifications may cause shifts in observed band size.

CamelBio: Your One‑Stop Sourcing Bridge

CamelBio partners with diagnostic developers and research laboratories by offering a streamlined supply of IVD raw materials, including validated antibodies, antigen‑grade peptides, and ancillary reagents. For ghrelin receptor (GHSR) studies, we can assist in sourcing polyclonal antibodies, matched antigen controls, and bulk‑order monoclonal options tailored to your assay development needs. Our platform also supports rare‑target sourcing and technical consulting, helping you accelerate projects from early‑stage research to clinical application.