Anti-GAS2 Monoclonal Antibody for WB - O43903

Core Product Specifications and Parameters

Biological Background: GAS2 Function and Localization

• Encoded by the GAS2 (growth arrest-specific 2) gene, giving rise to the growth arrest-specific protein 2, a 34.9 kDa protein (UniProt: O43903).
• Acts as a component of the cytoskeleton, primarily localizing to stress fibers and cytoplasm; also associates with the membrane.
• Essential for maintaining microtubule bundles in inner ear supporting cells, providing mechanical stiffness for sound energy transmission in the cochlea – mutations are linked to non-syndromic deafness.
• Ubiquitously expressed with highest levels in liver, lung, and kidney; absent from spleen.
• Classified under keywords: Alternative splicing, Apoptosis, Cell cycle, Cell shape, Cytoplasm, Cytoskeleton, Deafness, Growth arrest, Membrane, Non-syndromic deafness, Phosphoprotein.
• Potential roles in apoptosis and growth arrest, though molecular mechanisms remain to be fully elucidated.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1-100) of human GAS2, which is expected to generate antibodies recognizing this epitope; however, confirm reactivity in your specific experimental system.
• For Western blotting, a band around 35 kDa is anticipated in human, mouse, and rat samples; optimize sample preparation and antibody dilution based on your model.
• For ELISA, use the antibody as a capture or detection reagent, ensuring appropriate coating concentration and blocking conditions.
• Since GAS2 is involved in cytoskeletal dynamics and cochlear function, consider cell lines or tissues from ear, liver, lung, or kidney for endogenous expression studies.
• Cross-reactivity with other species should be verified if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive range of IVD raw materials, including validated antibody pairs, monoclonal and polyclonal antibodies, and bulk ancillary reagents, supporting diagnostic manufacturers and research laboratories from concept to clinic. For studies on hearing loss, cytoskeleton dynamics, or apoptosis, this anti-GAS2 antibody is part of CamelBio's portfolio of rare target raw materials. Contact our team to discuss custom sourcing, technical consulting, or scale-up procurement for your next project.