Anti-G0S2 Polyclonal Antibody for WB, ELISA - P27469

Core Product Specifications and Parameters

Biological Background: G0S2 Function and Localization

• G0S2 (G0/G1 switch protein 2, also known as G0/G1 switch regulatory protein 2) is a small protein of 103 amino acids (calculated molecular weight ~11.3 kDa) encoded by the G0S2 gene in humans.
• It functions as a pro-apoptotic factor by binding to the anti-apoptotic protein BCL2, thereby preventing the formation of protective BCL2-BAX heterodimers and promoting programmed cell death.
• G0S2 localizes to the mitochondria, consistent with its role in regulating the intrinsic apoptosis pathway.
• The protein is widely expressed across tissues, with highest mRNA levels observed in peripheral blood, skeletal muscle, and heart, and moderate expression in kidney and liver.
• As a member of the G0/G1 switch gene family, G0S2 is implicated in cell cycle regulation and transition from quiescence to proliferation.
• UniProt keywords include: Apoptosis, Mitochondrion, and Reference proteome, highlighting its role in cell death signaling.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal region (aa 1-100), which may be suitable for detecting both full-length and potential N-terminal fragments.
• For Western blot, the predicted molecular weight is 11 kDa; consider using a high-percentage gel (e.g., 15%) for optimal resolution.
• Validate antibody specificity in BCL2-overexpressing or G0S2-silenced cell models.
• In ELISA applications, pairing with a monoclonal capture antibody may enhance detection sensitivity for low-abundance endogenous G0S2.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers this G0S2 rabbit polyclonal antibody as part of a comprehensive portfolio for apoptosis research. From validated antibody pairs to bulk ancillary reagents and rare target sourcing, we support diagnostic developers and labs with one-stop access to high-quality IVD raw materials. Discuss your specific requirements with our team to accelerate your project from concept to clinic.