Anti-FXYD7 Polyclonal Antibody for WB, ELISA - P58549

Core Product Specifications and Parameters

Biological Background: FXYD7 Function and Localization

• FXYD7 is a member of the FXYD family of small ion transport regulators, characterized by a signature FXYD motif and a single transmembrane domain.
• It directly associates with and modulates the sodium/potassium-transporting ATPase (NKA), reducing the apparent affinity for external K+ and increasing the apparent affinity for intracellular Na+ in a voltage- and Na+-dependent manner. Related references: PMID:33231612
• The protein localizes to the cell membrane, consistent with its role as a transmembrane regulator.
• Post-translational modifications include glycosylation and phosphorylation, as annotated in UniProt.
• FXYD7 is involved in sodium and potassium ion transport, contributing to the maintenance of electrochemical gradients across the plasma membrane.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal region (aa 1-80) of human FXYD7; the resulting polyclonal antibody may recognize full-length and processed forms.
• In Western blot (WB), a band around 9 kDa is expected; consider using high-percentage gels for optimal separation.
• Validate cross-reactivity in mouse and rat systems if applicable, as preliminary data indicate reactivity with these species.
• For ELISA applications, titrate the antibody to determine optimal working dilutions in the relevant sample matrix.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated IVD raw-material partner, empowering diagnostic manufacturers and researchers with reliable, well-characterized antibodies like this anti-FXYD7 polyclonal antibody for sodium/potassium ATPase research. We provide one-stop access to validated reagents, including antibody pairs, bulk ancillary materials, and customized sourcing of rare targets, all supported by technical consulting to streamline your IVD development pipeline.