Anti-FUNDC1 Polyclonal Antibody for WB - Q8IVP5

Core Product Specifications and Parameters

Biological Background: FUNDC1 Function and Localization

• Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs).
  Related references: PMID:33972548
• Activates hypoxia-induced mitophagy by interacting with and recruiting LC3 protein family to mitochondria.
  Related references: PMID:22267086, PMID:24671035, PMID:24746696
• Recruits DRP1 at ER-mitochondria contact sites, promoting DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia.
  Related references: PMID:27145933, PMID:33978709
• Plays a role in hepatic ferroptosis by directly interacting with glutathione peroxidase GPX4 to facilitate its mitochondrial recruitment and mitophagy-dependent degradation.
  Related references: PMID:36828120
• Subcellularly located at the mitochondrion outer membrane.
• Widely expressed across tissues.
• Keywords: autophagy, membrane, phosphoprotein, and Ubl conjugation.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide covering amino acids 50-155; verify sequence homology when using in non-human species.
• For Western blot, a band around 17 kDa is expected for FUNDC1, but modifications or dimerization may shift mobility. Use appropriate controls and optimize blocking for clear results.
• In ELISA, the synthetic peptide can serve as a positive control to assess antibody reactivity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers integrated access to IVD raw materials for mitochondrial and autophagy research, including antibodies like this FUNDC1 polyclonal for mitophagy studies. We supply validated antibody pairs, bulk reagents, and custom sourcing solutions to support your diagnostic development from early stage to commercialization.