Anti-FSHR Rabbit Polyclonal Antibody for WB, IF-P, ELISA - P23945

Core Product Specifications and Parameters

Biological Background: FSHR Function and Localization

• FSHR is a G protein-coupled receptor that specifically binds follicle-stimulating hormone (follitropin), playing a central role in reproductive physiology. Related references: PMID:11847099 PMID:24058690 PMID:24692546
• Upon FSH binding, FSHR activates adenylyl cyclase, leading to cAMP production and subsequent stimulation of the PI3K-AKT and ERK1/ERK2 signaling pathways. Related references: PMID:24058690
• FSHR is predominantly expressed in testicular Sertoli cells and ovarian granulosa cells, where it regulates gametogenesis and steroidogenesis.
• The receptor localizes to the cell membrane and belongs to the glycoprotein hormone receptor subfamily of GPCRs.
• FSHR contains extracellular leucine-rich repeats and undergoes alternative splicing to generate multiple isoforms.
• Post-translational modifications such as glycosylation and sulfation modulate receptor function and trafficking.
• Mutations in FSHR are linked to reproductive disorders, highlighting its essential role in fertility.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal intracellular region (aa 631–695), which may confer specificity to full-length FSHR over potential splice variants.
• For WB, the predicted molecular weight is 78 kDa; confirm band size in your sample system and consider appropriate controls.
• For IF-P, validate antibody specificity in FSHR-expressing tissues such as testicular Sertoli cells or ovarian granulosa cells.
• For ELISA, consider pairing with capture antibodies recognizing distinct FSHR epitopes to establish a robust sandwich assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic manufacturers, laboratories, and research institutes with high-quality IVD raw materials. This anti-FSHR polyclonal antibody supports reproductive biomarker and GPCR-targeted assay development. Beyond single antibodies, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and customized sourcing for rare targets to streamline your entire workflow from concept to clinic.