Anti-FSH alpha/beta Rabbit Monoclonal Antibody for IF-P, IHC-P, ELISA - P01215 / P01225

Core Product Specifications and Parameters

Biological Background: FSH alpha/beta (CGA/FSHB) Function and Localization

• The glycoprotein hormones alpha chain (P01215) is encoded by the CGA gene and serves as a common subunit for the heterodimeric hormones TSH, LH, FSH, and CG.
• It forms biologically active hormones by pairing with distinct beta subunits; for FSH, the alpha chain associates with the FSHB-encoded beta subunit (P01225).
• These dimeric hormones bind to specific receptors on target cells, activating downstream signaling pathways essential for endocrine regulation.
• The protein is secreted and functions extracellularly as a circulating hormone.
• Structural features include disulfide bonds and glycosylation, consistent with its role as a glycoprotein hormone.
• Alternative names include choriogonadotropin alpha chain, lutropin alpha chain, thyrotropin alpha chain, and follitropin alpha chain.

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant protein, which may present conformational epitopes; anti-FSH alpha/beta reactivity should be validated in the relevant sample system.
• For IF-P and IHC-P, consider fixation methods (e.g., formalin-fixed paraffin-embedded sections) and antigen retrieval protocols to optimize detection.
• In ELISA, confirm coating and detection conditions using appropriate positive and negative controls, as antibody performance can vary with buffer systems and plate types.
• Given the shared alpha chain, cross-reactivity with other glycoprotein hormones (TSH, LH, CG) is possible; verify specificity in dual-labeling or multiplex assays.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with a comprehensive sourcing platform for IVD raw materials. This anti-FSH alpha/beta antibody supports reproductive endocrinology research and assay development, complementing our portfolio of validated antibody pairs and ancillary reagents. For specialized projects, CamelBio can assist in sourcing bulk quantities and rare-target materials to streamline your development workflow.