Anti-FRS2 Rabbit PolymAb® for WB, IHC-P, IF/ICC, ELISA - Q8WU20

Core Product Specifications and Parameters

Biological Background: FRS2 Function and Localization

• FRS2 (Fibroblast growth factor receptor substrate 2) is an adaptor protein that links activated FGF and NGF receptors to downstream signaling cascades, including the MAP kinase pathway and PI3K/AKT pathway via phosphorylation of PIK3R1.
• It modulates signaling through SHC1 by competing for a common binding site on NTRK1, thereby influencing neurotrophin signaling.
• The protein localizes to the endomembrane system.
• FRS2 is highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney, and testis.
• Post-translational modifications include myristoylation and phosphorylation; it is also subject to ubiquitination (Ubl conjugation).
• The protein has a molecular weight of approximately 57 kDa.

Experimental Guidance and Technical Tips

• For Western blot, consider using whole cell lysates from tissues with high FRS2 expression, such as heart, brain, or lung.
• For IHC-P and IF/ICC, validate staining in positive control tissues like heart or brain; include appropriate negative controls.
• As a recombinant rabbit monoclonal antibody, it offers high specificity and low batch-to-batch variation.
• Optimize antibody dilution and detection conditions in your specific experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive sourcing solutions for IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. This anti-FRS2 rabbit PolymAb® supports signal transduction research, and we can assist with rare target reagent procurement and technical consultation. Partner with CamelBio for reliable one-stop access from concept to clinic.