Anti-FPS/FDPS Monoclonal Antibody for WB, ELISA - P14324

Core Product Specifications and Parameters

Biological Background: FPS/FDPS Function and Localization

• Farnesyl pyrophosphate synthase (FDPS) is a key enzyme in isoprenoid biosynthesis, catalyzing the formation of farnesyl diphosphate (FPP) from isopentenyl pyrophosphate and dimethylallyl pyrophosphate.
• FPP serves as a precursor for essential metabolites including sterols, dolichols, carotenoids, and ubiquinones, and is a substrate for protein farnesylation and geranylgeranylation.
• FDPS belongs to the transferase family and is involved in cholesterol and steroid biosynthesis, as well as sterol metabolism.
• The enzyme localizes to the cytoplasm.
• Post-translational modifications include acetylation and hydroxylation, and the protein requires magnesium as a metal cofactor.
• Alternative splicing generates multiple isoforms, and FDPS is implicated in disease variants and host-virus interactions.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 67-419, covering most of the FDPS protein, which may enhance detection sensitivity and specificity in WB and ELISA applications.
• For WB, the predicted molecular weight is approximately 48 kDa; use appropriate gel percentage and transfer conditions.
• Since the antibody shows cross-reactivity with human, mouse, and rat, it can be applied in studies involving these species; however, validation in the relevant sample system is recommended.
• Consider optimizing antibody dilution and blocking conditions based on experimental setup.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a streamlined one-stop procurement solution for IVD raw materials, offering this anti-FDPS monoclonal antibody along with validated antibody pairs, bulk ancillary reagents, and custom sourcing for rare targets. Our expertise supports diagnostic developers and researchers in the isoprenoid biosynthesis and metabolic disease area, from concept to clinical application. Contact us to secure consistent, high-quality reagents for your workflow.