Anti-FOXP2 Polyclonal Antibody for WB, ELISA - O15409

Core Product Specifications and Parameters

Biological Background: FOXP2 Function and Localization

• FOXP2 is a forkhead box transcription factor that functions as a transcriptional repressor.
• It plays a critical role in lung epithelium specification and differentiation, as well as in neural, gastrointestinal, and cardiovascular tissue development.
• FOXP2 is involved in synapse formation by regulating SRPX2 levels and contributes to neural mechanisms underlying speech and language development.
• Multiple isoforms exist; isoform 1 and isoform 6 are detected in adult and fetal brain, caudate nucleus, and lung.
• The protein localizes to the nucleus and contains characteristic zinc-finger and forkhead DNA-binding domains.
• Key annotations include alternative splicing, chromosomal rearrangement, disease variant, DNA-binding, metal-binding, and transcriptional regulation.

Experimental Guidance and Technical Tips

• The polyclonal nature of this antibody may allow recognition of multiple FOXP2 isoforms; confirm specificity using isoform-specific controls.
• For WB, the predicted molecular weight is ~80 kDa (UniProt: 79919 Da), but post-translational modifications or alternative splicing may result in additional bands.
• Validate in the relevant sample system (e.g., lung or brain tissue lysates) to ensure optimal performance in your assay.
• For ELISA, consider using the recombinant immunogen as a positive control.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and researchers with reliable sourcing of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For studies on FOXP2—a key regulator in neurodevelopment and lung biology—we provide one-stop access to antibodies and related reagents tailored to your pipeline needs. Our expertise spans rare target sourcing and technical support to help advance your projects from concept to clinic.