Anti-FOXN2 Rabbit Polyclonal Antibody for WB and ELISA - P32314

Core Product Specifications and Parameters

Biological Background: FOXN2 Function and Localization

• FOXN2, also known as Human T-cell leukemia virus enhancer factor (HTLF), is a forkhead box transcription factor encoded by the FOXN2 gene.
• It binds specifically to the purine-rich region in the long terminal repeat (LTR) of human T-cell leukemia virus type I (HTLV-I), suggesting a role in viral transcription regulation.
• The protein localizes predominantly to the nucleus, consistent with its DNA-binding transcription factor function.
• FOXN2 is subject to alternative splicing, generating multiple isoforms that may exhibit distinct regulatory properties.
• Key structural motifs include a forkhead DNA-binding domain that mediates sequence-specific DNA recognition.
• It is classified under transcription factors and DNA-binding proteins, with involvement in transcription regulation.

Experimental Guidance and Technical Tips

• For Western blotting, consider using nuclear extracts to enrich FOXN2 signal given its nuclear localization.
• The immunogen spans amino acids 172-431, which includes the forkhead domain; thus, the antibody may recognize multiple isoforms.
• Validate antibody specificity in your system using appropriate controls, as polyclonal antibodies may exhibit batch-to-batch variation.
• For ELISA, optimize coating antigen concentration and use matched sample matrices to ensure consistent performance.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to IVD raw materials, including validated polyclonal antibodies, monoclonal antibody pairs, and bulk ancillary reagents. Our portfolio covers a wide range of transcription factors and viral research tools, ensuring reliable sourcing for assay development and biomarker studies. For rare targets like FOXN2, we offer customized antibody development and supply chain support to accelerate your diagnostic projects.