Anti-FOXI1 Polyclonal Antibody for WB, ELISA - Q12951

Core Product Specifications and Parameters

Biological Background: FOXI1 Function and Localization

• FOXI1, also known as Forkhead box protein I1, FKHL10, FREAC6, or HFH3, is a member of the forkhead/winged helix transcription factor family characterized by a conserved DNA-binding domain.
• Acts as a transcriptional activator essential for the development of normal hearing, sense of balance, and kidney function by regulating the expression of key target genes such as SLC26A4/PDS, JAG1, and COCH in inner ear epithelial cells, and SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 in renal intercalated cells (By similarity).
• Localizes to the nucleus where it exerts its transcriptional regulatory functions.
• Expressed specifically in the kidney.
• Undergoes alternative splicing, producing multiple isoforms that may have distinct functional roles.
• Required for the differentiation of intercalated cells in the epithelium of distal renal tubules, highlighting its role in epithelial cell specialization.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-100) of human FOXI1; for Western blot detection, consider using lysates from kidney or inner ear tissues where FOXI1 is expressed.
• For ELISA applications, the peptide immunogen can serve as a positive control; validate binding under your specific assay conditions.
• Due to cross-reactivity with mouse and rat, this antibody may be suitable for comparative studies; however, verify species-specific reactivity in your experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research teams by providing a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For projects targeting FOXI1—a critical factor in hearing, balance, and renal function—we can source rare-target antibodies and deliver customized solutions. From concept to clinic, CamelBio streamlines your procurement of high-quality raw materials and technical expertise.