Anti-FKBP6 Polyclonal Antibody for WB, IF/ICC, ELISA - O75344

Core Product Specifications and Parameters

Biological Background: FKBP6 Function and Localization

• FKBP6, also known as FKBP36 or FK506-binding protein 6, is an inactive peptidyl-prolyl cis-trans isomerase belonging to the immunophilin family.
• It plays an essential role in spermatogenesis by repressing transposable elements via the piRNA metabolic process, crucial for germline integrity. Related references: PMID:36150389
• FKBP6 acts as a co-chaperone with HSP90, facilitating the piRNA amplification process and secondary piRNA biogenesis during meiosis.
• Subcellularly, FKBP6 localizes to both the cytoplasm and nucleus.
• Expression is detected in various tissues, with higher levels in testis, heart, skeletal muscle, liver, and kidney.
• The protein contains TPR repeat motifs and is implicated in RNA-mediated gene silencing and germ cell differentiation.
• Genetic variants in FKBP6 are associated with Williams-Beuren syndrome and spermatogenic failure (SPGF77).

Experimental Guidance and Technical Tips

• The immunogen covers the full-length FKBP6 protein (aa 1-327), suggesting broad reactivity against endogenous targets across applications like WB, IF/ICC, and ELISA.
• For WB, consider using testis or heart lysates as positive controls due to higher FKBP6 expression in these tissues.
• In IF/ICC, anticipate cytoplasmic and nuclear staining; optimize fixation and permeabilization steps accordingly.
• Validate antibody specificity in your model system by including appropriate knockdown or knockout controls if available.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes with a seamless supply channel for IVD raw materials. Our portfolio includes polyclonal and monoclonal antibodies targeting key reproductive biology markers like FKBP6, supported by reliable supply chains for bulk ancillary reagents. From concept to clinic, CamelBio accelerates your assay development with one-stop sourcing solutions.