Anti-FKBP51/FKBP5 Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - Q13451

Core Product Specifications and Parameters

Biological Background: FKBP51/FKBP5 Function and Localization

• FKBP51/FKBP5 is an immunophilin with peptidyl-prolyl isomerase (PPIase) and co-chaperone activities. Related references: PMID:11350175
• It is a component of unligated steroid receptor heterocomplexes through interaction with HSP90, regulating intracellular trafficking and cytoplasmic retention of steroid hormone receptors. Related references: PMID:12538866
• FKBP5 acts as a regulator of Akt/AKT1 by promoting the interaction between Akt/AKT1 and PHLPP1, enhancing dephosphorylation and activation of Akt. Related references: PMID:28147277 PMID:28363942
• It interacts with IKBKE and IKBKB to facilitate IKK complex assembly, leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production. Related references: PMID:26101251 PMID:31434731
• Subcellular localization is mainly cytoplasmic but it can also be found in the nucleus.
• FKBP5 is widely expressed, with enrichment in testis, and undergoes post-translational modifications including acetylation, phosphorylation, and ubiquitination.

Experimental Guidance and Technical Tips

• For Western blotting (WB), consider using a positive control expressing FKBP5; expect a single band at the predicted molecular weight of approximately 51 kDa.
• In immunohistochemistry (IHC-P), validate staining patterns in known positive tissues (e.g., testis) and note both cytoplasmic and nuclear localization.
• For ELISA, confirm compatibility with the peptide immunogen region; the antibody’s reactivity to the target protein should be verified in the intended assay format.
• Cross-reactivity has been demonstrated with human and rat species; verify performance in other models if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a comprehensive range of IVD raw materials, including validated monoclonal antibodies, recombinant proteins, and ancillary reagents, supporting your assay development from concept to clinic. Our FKBP51/FKBP5 antibody is tailored for research in steroid receptor signaling, immunophilin biology, and stress-related pathways, offering reliable performance in WB, IHC-P, and ELISA applications. For bulk supply, optimized antibody pairs, or rare target sourcing, trust CamelBio as your dedicated B2B partner in diagnostic raw material procurement.