Anti-FKBP12 Rabbit Monoclonal Antibody for WB and ELISA - P62942

Core Product Specifications and Parameters

Biological Background: FKBP12 Function and Localization

• FKBP12 (FK506-binding protein 1A) is a 12 kDa peptidyl-prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imidic peptide bonds, facilitating protein folding.
• Functions as an immunophilin, binding immunosuppressant drugs FK506 and rapamycin, and is also known as FKBP-12 or Calstabin-1.
• Regulates TGF-beta signaling by maintaining the TGF-beta type I receptor (TGFBR1) in an inactive conformation, preventing ligand-independent receptor activation.
• Recruits SMAD7 to the activin receptor ACVR1B, blocking SMAD2/SMAD3 association and thereby inhibiting activin signal transduction.
• May modulate ryanodine receptor (RYR1) calcium channel activity in the sarcoplasmic reticulum.
• Localizes predominantly to the cytoplasm and cytosol, and is associated with the sarcoplasmic reticulum membrane.
• Post-translational modifications include acetylation (UniProt keyword 'Acetylation'), which may modulate its function or stability.

Experimental Guidance and Technical Tips

• The immunogen was designed from a conserved region (aa 29-108), which likely yields reactivity across human, mouse, and rat as indicated.
• For Western blot, a band at approximately 12 kDa is expected; consider using appropriate low molecular weight markers and optimized transfer conditions.
• In ELISA applications, the antibody may be used for capture or detection; validate performance in your specific assay format and sample matrix.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive sourcing partner for diagnostic manufacturers and research laboratories, providing one-stop access to IVD raw materials and technical expertise. For FKBP12 and related signaling pathways, we offer validated monoclonal antibodies, antibody pairs, and ancillary reagents in bulk, along with sourcing support for rare targets. Partner with CamelBio to streamline your development from concept to clinic.