Anti-FKBP11 Polyclonal Antibody for WB, ELISA - Q8N573

Core Product Specifications and Parameters

Biological Background: OXR1 (Oxidation Resistance Protein 1) Function and Localization

• OXR1 (Oxidation resistance protein 1) is encoded by the OXR1 gene and exists in multiple isoforms due to alternative splicing.
• Core function: OXR1 inhibits vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex, thereby regulating luminal pH in the Golgi apparatus and protecting glycosylation enzymes from excess acidification. Related references: PMID:38593795
• Oxidative stress protection: OXR1 plays a critical role in cellular defense against oxidative damage, enhancing survival under oxidative conditions. Related references: PMID:11114193, PMID:15060142
• Neuroprotection: OXR1 is particularly important for protecting neuronal cells from oxidative stress, contributing to neuronal health and function.
• Subcellular distribution: OXR1 localizes to multiple compartments, including the mitochondrion, nucleus (nucleolus), and Golgi apparatus (cis- and trans-Golgi network membranes), reflecting its multifaceted roles.
• Clinical relevance: Mutations in OXR1 are associated with neurological disorders such as epilepsy and intellectual disability, highlighting its importance in the nervous system.
• Post-translational modifications: OXR1 is a phosphoprotein, and its activity and localization may be regulated by phosphorylation.

Experimental Guidance and Technical Tips

• For Western blot, consider using reducing conditions and a positive control lysate from human, mouse, or rat tissue/cells expressing OXR1. The predicted molecular weight is ~98 kDa, so adjust gel percentage and transfer time accordingly.
• For ELISA, a secondary anti-rabbit IgG-HRP conjugate is recommended. Validate the assay with a known standard to ensure specificity.
• The immunogen corresponds to amino acids 28-150 of human FKBP11, but the annotated target based on SWISS Q8N573 is OXR1. Verify specificity in the relevant sample system, as cross-reactivity may reflect shared epitopes or dual targeting.
• Include appropriate controls such as knockdown lysates and loading controls to confirm signal specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research institutes a comprehensive sourcing solution for IVD raw materials, including validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents. For oxidative stress and neurological disorder research applications, we support procurement of rare target raw materials such as OXR1 antibodies and related proteins. Backed by our one-stop service model, we help accelerate your assay development from concept to clinic.