Anti-FGGY Polyclonal Antibody for WB, ELISA - Q96C11

Core Product Specifications and Parameters

Biological Background: FGGY Function and Localization

• FGGY (D-ribulokinase FGGY) is a carbohydrate kinase domain-containing protein that functions as a kinase/transferase.
• Catalyzes ATP-dependent phosphorylation of D-ribulose at C-5 to produce D-ribulose 5-phosphate, suggesting a role in metabolite repair to prevent toxic accumulation of free D-ribulose.
• May regulate D-ribulose 5-phosphate recycling within the pentose phosphate pathway; can also phosphorylate ribitol, albeit with low efficiency.
• Expressed primarily in kidney, lung, and small intestine, with lower levels in liver; detected in cerebrospinal fluid at the protein level.
• Keywords include alternative splicing, amyotrophic lateral sclerosis (ALS), and neurodegeneration, indicating potential disease associations.
• Part of the reference proteome and identified through proteomics.

Experimental Guidance and Technical Tips

• The immunogen spans the N-terminal region (amino acids 1-250) of human FGGY; consider this when designing experiments, as it may detect full-length and certain splice variants.
• For Western blotting, a band around 60 kDa is expected; validate the band size in your sample system and use appropriate loading controls.
• This polyclonal antibody is suitable for ELISA; titrate the antibody to determine optimal working concentrations for your assay.
• Cross-reactivity is reported for human, mouse, and rat; however, validation in the specific species and tissue is recommended for reproducibility.
• Since FGGY is involved in pentose phosphate metabolism, consider its expression modulation under metabolic stress conditions when interpreting results.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop platform for IVD raw material sourcing, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target procurement to diagnostic manufacturers and research laboratories. This anti-FGGY polyclonal antibody supports investigations into carbohydrate metabolism, metabolite repair, and neurodegenerative disease pathways. By bridging the gap from concept to clinic, CamelBio ensures reliable access to the critical reagents you need for assay development.