Anti-FGF17 Polyclonal Antibody for WB, IF/ICC, ELISA - O60258

Core Product Specifications and Parameters

Biological Background: FGF17 Function and Localization

• FGF17 (Fibroblast Growth Factor 17), also designated HH20, FGF-13, or FGF-17, is a secreted glycoprotein belonging to the fibroblast growth factor (FGF) family.
• It functions as a signaling molecule crucial for embryonic development, particularly in the induction and patterning of the embryonic brain, and is required for normal brain development.
• Expression is preferentially observed in the embryonic brain, consistent with its developmental role.
• Containing a signal peptide, FGF17 is secreted into the extracellular space where it mediates intercellular communication.
• Genetic alterations in FGF17 have been linked to Kallmann syndrome and hypogonadotropic hypogonadism, emphasizing its significance in neuroendocrine system development.
• FGF17 is subject to alternative splicing, generating protein isoforms that may have distinct regulatory roles.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 23–180 of human FGF17. This N-terminal region may be conserved across human, mouse, and rat, supporting the observed cross-reactivity.
• For WB, a specific band near 25 kDa is expected. Include appropriate positive controls (e.g., embryonic tissue or FGF17-expressing cell lines) to confirm detection.
• For IF/ICC, verify the secreted protein’s localization pattern; co-staining with a Golgi marker may be helpful to capture intracellular pools before secretion.
• For ELISA, use recombinant FGF17 protein as a standard to validate assay performance.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting. As a sourcing partner, CamelBio offers validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and supports rare target raw-material procurement. For FGF17-related research in developmental biology and neuroendocrine disorders, CamelBio can assist with custom antibody development and assay optimization.