Anti-FBXL12 Polyclonal Antibody for WB and ELISA - Q9NXK8

Core Product Specifications and Parameters

Biological Background: FBXL12 Function and Localization

• FBXL12 (F-box/LRR-repeat protein 12), also known as FBL12, is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex.
• It mediates polyubiquitination and proteasomal degradation of CAMK1, leading to disruption of cyclin D1/CDK4 complex assembly and G1 cell cycle arrest in lung epithelia.
• The protein contains an F-box domain and leucine-rich repeats, classifying it as a member of the FBXL subfamily of F-box proteins.
• Alternative splicing of the FBXL12 gene yields multiple transcript variants, contributing to functional diversity.
• FBXL12 is involved in the ubiquitin-proteasome system, a key pathway for protein homeostasis and cell cycle regulation.
• Its molecular weight is calculated as approximately 37 kDa, consistent with the antibody's detection size on Western blots.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 1-326 of human FBXL12; consider validating antibody performance in your specific sample system.
• This antibody is recommended for Western blot (WB) and ELISA applications; optimal dilutions must be determined experimentally.
• As a polyclonal antibody, it may recognize multiple epitopes; confirm specificity by testing in knockout or knockdown models.
• Cross-reactivity has been reported for human and mouse; reactivity with other species should be individually verified.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive one-stop platform for IVD raw materials, enabling researchers and diagnostic manufacturers to source high-quality antibodies, antigens, and ancillary reagents with ease. With expertise in ubiquitin-proteasome pathway targets like FBXL12, CamelBio provides validated antibody pairs, optimized polyclonal and monoclonal antibodies, and bulk ancillary reagents to accelerate your assay development from concept to clinic. Backed by a robust supply network and technical support, we help you secure even rare-target raw materials efficiently, ensuring reliable and consistent performance for your diagnostic kits.