Anti-FASTKD2 Polyclonal Antibody for WB, IHC-P, ELISA - Q9NYY8

Core Product Specifications and Parameters

Biological Background: FASTKD2 Function and Localization

• FASTKD2 (FAST kinase domain-containing protein 2) is a mitochondrial protein encoded by the FASTKD2 gene, also known as COXPD44 or KIAA0971.
• It plays an important role in the assembly of the mitochondrial large ribosomal subunit by functioning as part of a protein-RNA module that controls 16S mitochondrial ribosomal RNA (mt-rRNA) abundance, which is required for intra-mitochondrial translation. Related references: PMID:25683715 PMID:26370583 PMID:27667664
• May also play a role in mitochondrial apoptosis.
• Subcellular localization is primarily in the mitochondrion matrix and nucleoid.
• Expression is highest in heart, smooth muscle, and thyroid, with detection in a wide range of tissues including spleen, thymus, testis, ovary, colon, kidney, brain, lung, and liver.
• Post-translational modifications include phosphorylation (phosphoprotein), and the protein undergoes alternative splicing.
• Variants in FASTKD2 are associated with primary mitochondrial disease, specifically combined oxidative phosphorylation deficiency 44 (COXPD44).

Experimental Guidance and Technical Tips

• The immunogen used is a synthetic peptide corresponding to amino acids 51–150 of human FASTKD2, an N-terminal region. This design may enable detection of full-length endogenous protein.
• For Western blotting, a band at approximately 81 kDa is expected; verify in your sample system.
• The antibody is listed for use in WB, IHC-P, and ELISA. Consider appropriate antigen retrieval for IHC-P and proper blocking for ELISA.
• Cross-reactivity has been reported for human and mouse; validate in your specific model to confirm.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your comprehensive partner for IVD raw materials, connecting diagnostic manufacturers, laboratories, and research institutes with the critical components needed from concept to clinic. This FASTKD2 antibody supports mitochondrial research and translational applications, and is part of our broader offering that includes validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk reagents, and rare-target sourcing expertise.