Anti-FAR1 Polyclonal Antibody for WB, ELISA - Q8WVX9

Core Product Specifications and Parameters

Biological Background: FAR1 Function and Localization

• FAR1 (Fatty acyl-CoA reductase 1), also known as male sterility domain-containing protein 2 (MLSTD2), is a member of the fatty acyl-CoA reductase family.
• Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. Related references: PMID:15220348 PMID:24108123 PMID:35238077
• Plays an essential role in the production of ether lipids/plasmalogens, which require fatty alcohols for their synthesis. Related references: PMID:20071337 PMID:24108123 PMID:33239752
• Is also required for wax monoester production, as fatty alcohols serve as substrates for this process. Related references: PMID:24108123 PMID:35238077
• Localizes to the peroxisome membrane and contains transmembrane helices.
• Utilizes NADP as a cofactor for its oxidoreductase activity.
• Genetic variants of FAR1 have been linked to cataracts, epilepsy, and intellectual disability.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1–100 of human FAR1, which may allow detection of full-length protein. As a polyclonal antibody, it recognizes multiple epitopes, potentially reducing the impact of minor sequence variations.
• For Western blotting, a band near 59 kDa is expected. Use appropriate human positive control lysates or cell lines known to express FAR1.
• In ELISA, the antibody can serve as either capture or detection antibody; perform titration and validation experiments to determine optimal working dilutions.
• Cross-reactivity is reported only for human; if used on samples from other species, validate via sequence homology and experimental testing.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop sourcing partner for IVD raw materials, providing comprehensive support for lipid metabolism and peroxisome research. We offer a wide range of validated antibodies, including polyclonals like this anti-FAR1, along with antibody pairs, mono-specific reagents, bulk ancillary supplies, and flexible sourcing for rare targets. Contact us to streamline your procurement from discovery to clinical application.