Anti-FAM129B Rabbit Polyclonal Antibody for WB, ELISA - Q96TA1

Core Product Specifications and Parameters

Biological Background: FAM129B Function and Localization

• FAM129B, also known as Niban 2, Meg-3, or MINERVA, is encoded by the NIBAN2 (FAM129B) gene and undergoes alternative splicing.
• The protein is reported to play a role in apoptosis suppression, potentially contributing to cell survival under stress conditions.
• FAM129B may promote melanoma cell invasion in vitro, suggesting involvement in cancer metastasis.
• It localizes to the cytoplasm, cytosol, cell adherens junctions, and membrane, indicating dynamic distribution.
• Classified as a lipoprotein and myristoylated protein, FAM129B is subject to phosphorylation, as identified by proteomics.
• No tissue-specific expression data is currently annotated, but its presence in melanoma cells is implied.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 447-746 of human FAM129B (NP_073744.2); verify its specificity for your target isoform in relevant cell lysates.
• For Western blotting, a band around 84 kDa is expected; optimize lysate preparation and antibody dilution empirically.
• ELISA applications may require direct immobilization of the immunogen or capture format; validate with purified protein or known positive samples.
• Consider cross-reactivity to other Niban family members; when specificity is critical, perform siRNA knockdown or use blocking peptides.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio connects diagnostic manufacturers and research labs with high-quality IVD raw materials, offering a streamlined sourcing experience from concept to clinic. This anti-FAM129B antibody supports apoptosis and cancer invasion research, with potential applications in oncology diagnostic assay development. In addition to this antibody, we supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and can assist in sourcing hard-to-find raw materials for rare disease targets.