Anti-FAM107A Rabbit Polyclonal Antibody for WB, ELISA - O95990

Core Product Specifications and Parameters

Biological Background: FAM107A Function and Localization

• Actin-associated protein FAM107A (also known as DRR1, TU3A) is encoded by the FAM107A gene and undergoes alternative splicing.
• Core function as a stress-inducible actin-binding protein: mediates polymerization of globular actin to F-actin, stabilizes and bundles F-actin, and contributes to synaptic functions such as neurite outgrowth and hippocampus-dependent cognitive processes (By similarity).
• Involved in actin and microtubule cytoskeleton organization; negatively regulates focal adhesion assembly, promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner. Related references: PMID:20543869
• Inhibits neuroblastoma G1/S phase cell cycle progression by stimulating ubiquitination and degradation of NF-kappa-B subunit RELA in a COMMD1- and actin-dependent manner. Related references: PMID:10564580, PMID:28604741
• Subcellular localization includes nucleus, cytoplasm, stress fibers, focal adhesions, ruffle membranes, and synapses.
• Widely expressed, notably in neurons and malignant glial tumors; expression is reduced or absent in many cancer cell lines. Related references: PMID:10564580
• May play a role in tumor development. Related references: PMID:10564580

Experimental Guidance and Technical Tips

• For Western blot (WB), the predicted molecular weight is approximately 17 kDa; validate detection in appropriate human or mouse cell/tissue lysates.
• ELISA applications may require optimization of coating antigen concentration and antibody dilution; consider using the recombinant immunogen as a positive control.
• Because the antibody cross-reacts with mouse, it can be utilized for studies involving mouse models, though validation in the specific sample type is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with end-to-end access to IVD raw materials, including validated antibody pairs, bulk monoclonal/polyclonal antibodies, and ancillary reagents. This anti-FAM107A polyclonal antibody supports research into actin dynamics, synaptic biology, and tumor development. From rare-target sourcing to routine supply, CamelBio streamlines your project from concept to clinic.