Anti-FAM107A Polyclonal Antibody for WB, ELISA - O95990

Core Product Specifications and Parameters

Biological Background: FAM107A Function and Localization

• FAM107A (also designated DRR1 or TU3A) is a stress-inducible actin-binding protein that promotes actin polymerization and stabilizes/bundles filamentous actin (F-actin), essential for synaptic functions such as neurite outgrowth and hippocampus-dependent cognitive processes.
• Negatively regulates focal adhesion (FA) assembly to facilitate malignant glial cell migration in an actin-, microtubule-, and MAP1A-dependent manner.
  Related references: PMID:20543869
• Inhibits G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination and degradation of the NF-kappa-B subunit RELA through a COMMD1- and actin-dependent pathway.
  Related references: PMID:10564580 PMID:28604741
• May contribute to tumor development, as its expression is frequently downregulated in cancer cell lines.
  Related references: PMID:10564580
• Localizes to multiple subcellular compartments, including the nucleus, cytoplasm, stress fibers, focal adhesions, ruffle membranes, and synapses, reflecting its roles in cytoskeletal organization and cell adhesion.
• Widely expressed in normal tissues, with prominent presence in neurons and malignant glial tumors, but reduced or absent in many cancer types.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal 1–144 amino acids of human FAM107A; a band at approximately 17 kDa is expected in Western blot assays on appropriate lysates.
• For ELISA, pairing with a matched detection antibody may improve sensitivity; validate cross-reactivity with mouse and rat samples, as indicated.
• Optimization of antibody dilution in the specific sample system is recommended, as expression of FAM107A can vary among cell lines and tissues.
• Given the multi-compartment localization of FAM107A, consider subcellular fractionation or co-immunostaining to confirm target-specific interactions.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated IVD raw-material sourcing partner, supplying validated antibody pairs, monoclonal and polyclonal antibodies, and ancillary reagents to accelerate diagnostic and research programs. This anti-FAM107A polyclonal antibody belongs to a portfolio addressing actin dynamics and cancer biology, enabling streamlined procurement for projects investigating cytoskeletal regulation and tumorigenesis. For bulk requirements, customized antibody development, or rare target sourcing, our team offers end-to-end support from concept to clinic.