Anti-EXOSC8 Rabbit Polyclonal Antibody for WB, ELISA - Q96B26

Core Product Specifications and Parameters

Biological Background: EXOSC8 Function and Localization

• EXOSC8 encodes the exosome complex component RRP43, a non-catalytic subunit of the RNA exosome complex, which provides a scaffold for catalytic subunits and accessory proteins.
• The RNA exosome is a multi-protein complex that exhibits 3'→5' exoribonuclease activity, participating in processing and degradation of various RNA species including rRNA, snRNA, snoRNA, and mRNA.
• EXOSC8 specifically binds to AU-rich elements (AREs) within the 3' untranslated regions of mRNAs, targeting inherently unstable transcripts for degradation.
• The exosome functions in both the nucleus and cytoplasm: in the nucleus, it matures stable RNAs and eliminates processing by-products and pervasive transcripts; in the cytoplasm, it mediates general mRNA turnover and surveillance.
• Subcellular localization includes the cytoplasm, nucleus, and nucleolus, reflecting its dynamic roles in RNA metabolism.
• Alternative names for EXOSC8 include OIP2 (Opa-interacting protein 2), RRP43 (Ribosomal RNA-processing protein 43), and p9, highlighting its interactions and processing functions.
• Keywords associated with EXOSC8 include RNA-binding, rRNA processing, acetylation, and neurodegeneration, indicating its regulatory roles and disease relevance.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant fusion protein spanning amino acids 1-276 of human EXOSC8, providing a broad antigenic region for polyclonal antibody generation; consider verifying reactivity against endogenous protein in relevant cell lysates.
• This antibody is validated for Western blot (WB) and ELISA applications; for other assays, further optimization and validation in your specific sample system are recommended.
• Cross-reactivity is confirmed for human; when using non-human samples, cross-species reactivity should be experimentally determined.
• The predicted protein weight is approximately 30 kDa; consider using appropriate gel percentages and molecular weight markers for clear detection.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as your comprehensive partner for IVD raw material sourcing, offering validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. This EXOSC8 antibody is ideal for research into RNA processing, exosome complex functions, and associated disease mechanisms. We also assist in sourcing rare target raw materials to accelerate your diagnostic development from concept to clinic.